

Like its real-life counterpart, Los Santos is a huge and sprawling metropolis with various different cultures, ranging from the prestigious film-making industry of Vinewood to the suburban hood life of Strawberry, just to name a few. Los Santos is Spanish for "The Saints", a play on "The Angels", which is the translation of Los Angeles. Los Santos is based on Los Angeles, California and its greater metropolitan area.

The new rendition of the city is much more detailed, larger, and looks more alive than ever before. GTA V marks Los Santos' second appearance in the series after its 3D Universe counterpart in Grand Theft Auto: San Andreas, which came out in 2004. The City of Los Santos, commonly known as Los Santos and often abbreviated as L.S., is a major city located in southern San Andreas in Grand Theft Auto V and Grand Theft Auto Online.
